A case-control study on cryopreserved versus non-cryopreserved strategies for autologous hematopoietic cell transplantation in multiple myeloma
DOI:
https://doi.org/10.46765/2675-374X.2025v6n1e251Keywords:
Multiple Myeloma, Hematopoietic Stem Cell TransplantationAbstract
Background: Autologous hematopoietic cell transplantation (aHCT) is a standard treatment for Multiple Myeloma (MM). The classic practice is with cryopreservation of the peripheral blood stem cells (PBSC) in the period from collection to infusion, but non-cryopreserved storage at 4oC has demonstrated to be feasible and safe. Methods: Here we present a retrospective, case-control study comparing the outcomes in terms of engraftment in two centers in Uruguay, one with cryopreservation (Hospital Británico-HB) and the other with 4oC storage (Hospital Maciel-HM). Results: 69 patients were included during Oct 15, 2018 and Dec 23, 2023. Median age was 60 years old (32-72). The median of collected PBSC was 9.0 x 106/kg (range 2.7 - 32.3), and the median of PBSC infused was 5.4 x 106/kg, (range 2.7 - 10.8). The time to neutrophil engraftment was 10 days (range 6-12) in HM and 9 days (range 7-12) in HB (p=0.38). The time for platelet engraftment was 20 days (range 17-25) in HM and 19 days (range 15-30) in HB (p=0.14). There were no graft failures, and no treatment-related mortality was observed at 100 days. Conclusions: Both cryopreserved and non-cryopreserved strategies appear to achieve similar outcomes in terms of engraftment and safety. Non-cryopreservation could be a way to improve affordability and accessibility to aHCT in MM, particularly in resource-limited areas.
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Copyright (c) 2025 Byron Figueroa, Martin Ferrando, Sebastian Galeano, Gabriel Borelli, Eloísa Riva, Alberto Vásquez, Carolina Oliver, Rosanna De Giuda, Silvia Pierri, Leticia Martinez, Melanie Isern, Claudia Martinez, Romina Urrutia, Cristina Otero, Victoria Irigoín, Victoria Remedi, Martina Perdomo, María Mori, Regis Gai, Estefanía López, Virginia Marcalain, Camila Guidali, Laura Bello, Virginia Moraes, Lourdes Viano, Analía Olivera, Carina Lamela, Carla Ambrosini, Silvia Pisano, Juan Ferrari, Jimena Prieto, Raul Gabús, Pablo Muxí, Ana Inés Landoni
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