Haploidentical Hematopoietic Stem-cell Transplant for High-Risk Acute Myeloid Leukemia in a Kidney Transplant Recipient: Case Report

Abstract

Solid organ transplantation is associated with a higher incidence of malignancies. Among them, acute myeloid leukemia has high morbidity and mortality, and its cure is only possible through allogeneic hematopoietic stem cell transplantation for high-risk disease. Case report: A 32-year-old female who underwent a kidney transplant eight years before was diagnosed with high-risk acute myeloid leukemia. She underwent induction therapy with “7+3”, achieving complete remission with measurable residual disease detectable by flow cytometry. She then underwent a myeloablative haploidentical allogeneic transplant, achieving complete remission, free of graft-versus-host disease, with a functioning renal graft.