Central nervous system tumors

Gustavo Zamperlini; Paulo Henrique dos Santos Klinger; Antonella Zanette; Cilmara Kuwahara; Sidnei Epelman; Adriana Seber; Cláudio Galvão de Castro Junior

doi:10.46765/2675-374X.2025v6n1e284

Central nervous system tumors

Authors

Gustavo Zamperlini Centro Infantil Boldrini – Campinas (SP), Brazil. https://orcid.org/0009-0002-9007-7652
Paulo Henrique dos Santos Klinger Hospital Santa Marcelina – São Paulo (SP), Brazil. https://orcid.org/0000-0001-6739-062X
Antonella Zanette Hospital Erastinho – Curitiba (PR), Brazil. https://orcid.org/0009-0002-2511-7208
Cilmara Kuwahara Hospital Pequeno Principe – Curitiba (PR), Brazil. https://orcid.org/0000-0001-9812-7437
Sidnei Epelman Hospital Santa Marcelina – São Paulo (SP), Brazil. https://orcid.org/0000-0002-6656-2992
Adriana Seber Hospital Samaritano de São Paulo – São Paulo (SP), Brazil |Hemacore – São José dos Campos (SP), Brazil. https://orcid.org/0000-0003-4578-9423
Cláudio Galvão de Castro Junior Hemacore – São José dos Campos (SP), Brazil | Certho – Guaratinguetá (SP), Brazil. https://orcid.org/0000-0002-4610-8282

DOI:

https://doi.org/10.46765/2675-374X.2025v6n1e284

Keywords:

Central Nervous System Tumors, Pediatrics, Children, High Dose Chemotherapy, Autologus Stem Cell Transplant

Abstract

Central nervous system (CNS) tumors represent one of the most prevalent groups of neoplasms in the pediatric population. Recent advances in molecular biology and neuro-oncology have led to continuous updates in the classification of these tumors, which poses significant diagnostic challenges, particularly in low- and middle-income countries, with limited access to advanced diagnostic tools. The therapeutic approach varies according to tumor subtype, often requiring complex and resource-intensive protocols. One such strategy involves the use of high-dose chemotherapy followed by autologous stem cell rescue, which has shown promise in improving outcomes for select pediatric patients with CNS tumors. However, implementation of this therapy in countries like Brazil faces logistical, financial, and clinical practice challenges. This article aimed to provide a brief overview and suggestions to use high-dose chemotherapy with autologous stem cell transplantation in the treatment of pediatric CNS tumors. We discussed practical considerations for patient selection, and conditioning regimens. Our objectives were to optimize and guide current practices by proposing strategies that maybe feasible in the Brazilian public and private healthcare systems.

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10/18/2025

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Zamperlini, G., Klinger, P. H. dos S., Zanette, A., Kuwahara, C., Epelman, S., Seber, A., & Castro Junior, C. G. de. (2025). Central nervous system tumors. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 6(1). https://doi.org/10.46765/2675-374X.2025v6n1e284

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Central nervous system tumors

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