Sickle cell disease

Luiz Guilherme Darrigo Junior; Roseane Vasconcelos Gouveia; Cilmara Kuwahara; Alexandre de Albuquerque Antunes; Adriana Martins de Sousa; Ana Karine Vieira; Ainá Henriques Melgaço; Juliana Folloni Fernandes; Adriana Seber

doi:10.46765/2675-374X.2025v6n1e294

Sickle cell disease

Authors

Luiz Guilherme Darrigo Junior Universidade de São Paulo – Hospital das Clínicas – Ribeirão Preto (SP), Brazil. https://orcid.org/0000-0001-6007-8908
Roseane Vasconcelos Gouveia Hospital Samaritano de São Paulo – São Paulo (SP), Brazil|Universidade Federal de São Paulo – Escola Paulista de Medicina – São Paulo (SP), Brazil|Grupo de Apoio ao Adolescente e à Criança com Câncer – São Paulo (SP), Brazil. https://orcid.org/0000-0002-9370-7878
Cilmara Kuwahara Hospital Pequeno Príncipe – Curitiba (PR), Brazil. https://orcid.org/0000-0001-9812-7437
Alexandre de Albuquerque Antunes Hospital da Criança de Brasília José de Alencar – Brasília (DF), Brazil. https://orcid.org/0000-0002-6885-3363
Adriana Martins de Sousa Universidade Federal do Rio de Janeiro – Instituto de Puericultura e Pediatria Martagão Gesteira – Rio de Janeiro (RJ), Brazil. https://orcid.org/0000-0001-8599-2974
Ana Karine Vieira Universidade Federal de Minas Gerais – Hospital das Clínicas – Belo Horizonte (MG), Brazil|Grupo Santa Casa de Belo Horizonte – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0002-8289-8461
Ainá Henriques Melgaço Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti – Rio de Janeiro (RJ), Brazil|Hospital Geral de Bonsucesso – Rio de Janeiro (RJ), Brazil. https://orcid.org/0009-0008-2997-0496
Juliana Folloni Fernandes Hospital Israelita Albert Einsten – São Paulo (SP), Brazil. https://orcid.org/0000-0002-5764-1621
Adriana Seber Hospital Samaritano de São Paulo – São Paulo (SP), Brazil|Universidade Federal de São Paulo – Escola Paulista de Medicina – São Paulo (SP), Brazil. https://orcid.org/0000-0003-4578-9423

DOI:

https://doi.org/10.46765/2675-374X.2025v6n1e294

Keywords:

Anemia, Sickle Cell, Hematopoietic Stem Cell Transplantation, Hematology, Pediatrics

Abstract

Sickle cell disease (SCD) is known as the most common hemoglobin disorder, with severe forms of thalassemia syndromes following closely. Current standard treatments, including transfusions, hydroxyurea, and L-glutamine, still do not significantly improve life expectancy and quality of life for patients. Allogeneic hematopoietic cell transplantation (HCT) remains the only curative option, showing overall survival and event-free survival rates over 90%, especially in patients under 16 years old. However, only 15% of SCD patients have access to an unaffected family donor. To increase donor availability, alternative sources such as matched unrelated donors, unrelated umbilical cord blood, and haploidentical donors have become viable options for patients without a matched related donor. The aim of this article was to update the Brazilian consensus previously published by the Brazilian Society of Cellular Therapy and Bone Marrow Transplantation in 2021, highlighting the latest developments in the treatment and monitoring of patients with SCD undergoing HCT.

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10/20/2025

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Darrigo Junior, L. G., Gouveia, R. V., Kuwahara, C., Antunes, A. de A., Sousa , A. M. de, Vieira, A. K., … Seber, A. (2025). Sickle cell disease. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 6(1). https://doi.org/10.46765/2675-374X.2025v6n1e294

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Vol. 6 No. 1 (2025): Journal of Bone Marrow Transplantation and Cellular Therapy

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Pediatric Consensus Updates

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Copyright (c) 2025 Luiz Guilherme Darrigo Junior, Roseane Vasconcelos Gouveia, Cilmara Kuwahara, Alexandre de Albuquerque Antunes, Adriana Martins de Sousa , Ana Karine Vieira, Ainá Henriques Melgaço, Juliana Folloni Fernandes, Adriana Seber

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Sickle cell disease

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