Current activity trends and outcomes of hematopoietic cell transplantation: A 2026 report from the Brazilian Registry of Hematopoietic Cell Transplantation in collaboration with the CIBMTR & SBTMO
DOI:
https://doi.org/10.46765/2675-374X.2025v7n1e353Keywords:
Data management, Hematopoietic cell transplant, CIBMTR, SBTMO, Brazilian Summary SlidesAbstract
The development of the Brazilian Registry of Hematopoietic Cell Transplantation (Registro Brasileiro de Transplantes de Células Hematopoieticas), in collaboration with the Center for International Blood and Marrow Transplant Research (CIBMTR), continues to provide a comprehensive assessment of hematopoietic cell transplantation (HCT) activity and outcomes in Brazil. In this study, we report an updated analysis of national transplant activity. Brazilian transplant centers report their data to the CIBMTR using the FormsNet3 platform, and data are returned to the Brazilian Society of Cellular Therapy and Bone Marrow Transplantation (Sociedade Brasileira de Terapia Celular e Transplante de Medula Óssea) through the Data Back to Centers (DBtC) tool. Data from patients who underwent HCT from 2015 to 2025 in Brazilian centers were extracted from the CIBMTR. Descriptive analyses were performed using patient-, disease-, and transplant-related variables, and overall survival was estimated using the Kaplan–Meier method. A total of 15,586 HCTs were included (7,507 autologous and 8,079 allogeneic). For survival analyses, 9,150 patients who underwent a first HCT from 2015 to 2023 were analyzed, with a median follow-up of 35 months. The number of reporting centers increased over time, reaching 51 centers during the study period. Acute leukemias remained the most common indication for allogeneic HCT, while multiple myeloma and lymphomas predominated in autologous HCT. In recent years, mismatched related donors have accounted for the largest proportion of allogeneic transplants. Bone marrow was the main graft source in pediatric patients, whereas peripheral blood predominated in adults. Infections were the most frequent cause of death within the first 100 days after HCT, while primary disease was the leading cause beyond 100 days. Survival patterns varied according to disease characteristics and transplantrelated factors, with lower survival estimates observed in patients transplanted with advanced disease stages. Comparisons with the United States Summary Slides suggest both similarities and differences in transplant activity and outcomes, which should be interpreted with caution given variations in data structure, patient characteristics, and risk stratification.
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Copyright (c) 2026 Anderson João Simione, Cinthya Corrêa da Silva, Afonso Celso Vigorito, Antonio Vaz Macedo, Heliz Regina Alves das Neves, Vanessa Aparecida do Nascimento Varjão, Monique Ammi, Flavia Ferreira da da Costa, Adriana Mendes de Quadros Cavilha, Alayne Magalhães T.D. Yamada, Vergilio Antonio Rensi Colturato, Phillip Scheinberg, Samir Kanaan Nabhan, Decio Lerner, Nelson Hamerschlak, Marcos Paulo Colella, George Maurício Navarro Barros, Alexandre Silvério, Adriana Seber, Simone Ojima Ferreira, Yana Augusta Sarkis Novis, Andreia Ribeiro de Almeida, Vanderson Geraldo Rocha, Maria Claudia Rodrigues Moreira, Claudia Caceres Astigarraga, Liane Esteves Daudt, Maria Cristina Martins de Almeida Macedo, Ricardo Chiattone, Juliana Folloni Fernandes, Volney Assis Lara Vilela, Rodolfo Daniel de Almeida Soares, Gustavo Machado Teixeira, Celso Arrais-Rodrigues, Roberto Luiz da Silva, Vaneuza Araújo Moreira Funke, Jayr Schmidt Filho, Vinicius Campos de Molla, João Samuel de Holanda Farias, Ricardo Pasquini, Carmem Maria Sales Bonfim, Abrahão Elias Hallack Neto, Rodolfo Froes Calixto, João Victor Piccolo Feliciano, Rafael Dezen Gaiolla, Marcelo Capra, Angelo Atalla, Milton Alexandre Ferreira Aranha, Rony Schaffel, Gianne Donato Costa Veloso, Fernando Sergio Blumm Ferreira, Andresa Lima Melo, Simone de Castro Resende Franco, Marcelo Alves Aduan, Andreza Alice Feitosa Ribeiro, Thiago Xavier Carneiro, Wellington Moraes de Azevedo, Giancarlo Fatobene, Abel da Costa Neto, Marcelo C. Pasquini, Mary E. Flowers, Fernando Barroso Duarte
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