Hematopoietic progenitor cell mobilization, collection, transportation, and infusion of fresh products

Authors

  • Karen Lima Prata Fundação Centro de Hematologia e Hemoterapia de Minas Gerais – Belo Horizonte (MG), Brazil|Agência Transfusional – Hospital das Clínicas da Universidade Federal de Minas Gerais – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0003-0909-8166
  • Andrea Tiemi Kondo Departamento de Hemoterapia e Terapia Celular – AC Camargos Câncer Center – São Paulo (SP) Brazil. https://orcid.org/0000-0002-4228-8503
  • Karine Sampaio Nunes Barroso Centro de Hematologia e Hemoterapia do Ceará – Fortaleza (CE), Brazil|Unidade de Transplante de Medula Óssea do Hospital Universitário Walter Cantídio – Fortaleza (CE), Brazil|Hospital Unimed Fortaleza – Fortaleza (CE), Brazil. https://orcid.org/0000-0002-5346-9414
  • Aline Miranda de Souza Grupo GSH – São Paulo (SP), Brazil. https://orcid.org/0000-0001-6276-1751
  • Andreza Alice Feitosa Ribeiro Centro de Excelência em Transplante de Medula Óssea do Hospital Israelita Albert Einstein – São Paulo (SP) Brazil. https://orcid.org/0009-0008-9570-1876

DOI:

https://doi.org/10.46765/2675-374X.2025v7n1e362

Keywords:

Mobilization, Stem cell collection, Stem cell infusion, Transportation, Bone marrow harvest, Leukapheresis

Abstract

Introduction: The quality of the graft is a critical determinant of transplant success. Methods: Literature review and expert discussion. Results: In this review, we highlight the essential aspects of hematopoietic progenitor cell mobilization and collection, including apheresis and bone marrow harvest. We also discuss optimal cell dose and concentration, as well as key considerations for product labeling, transportation, and infusion of fresh cell therapy products. Conclusion: This document contains recommendations based on the best scientific evidence available at the time of its publication. We hope it proves useful in the daily operations of a bone marrow transplant unit.

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Published

08/10/2026

How to Cite

Prata, K. L., Kondo, A. T., Barroso, K. S. N., Souza, A. M. de, & Ribeiro, A. A. F. (2026). Hematopoietic progenitor cell mobilization, collection, transportation, and infusion of fresh products. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 7(1). https://doi.org/10.46765/2675-374X.2025v7n1e362

Issue

Vol. 7 No. 1 (2026): Journal of Bone Marrow Transplantation and Cellular Therapy

Section

Adult Consensus Updates

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Copyright (c) 2026 Karen Lima Prata, Andrea Tiemi Kondo, Karine Sampaio Nunes Barroso, Aline Miranda de Souza, Andreza Alice Feitosa Ribeiro

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This work is licensed under a Creative Commons Attribution 4.0 International License.