Natural killer cell biology
DOI:
https://doi.org/10.46765/2675-374X.2025v7n1e366Keywords:
ller Cells, Natural, Lymphocytes, Cell BiologyAbstract
Innate lymphocytes can acquire phenotypes and functions determined by an organ or tissue, or by a \ niche within these microenvironments. On the other hand, they can exhibit transient phenotypes and functions—with different amounts or densities of the same receptors. Natural killer cells, as innate lymphocytes, can also have different functions or phenotypes and are primarily tissue-resident lymphocytes.
References
1. Silla L, Valim V, Pezzi A, da Silva M, Wilke I, Nobrega J, Vargas A, Amorin B, Correa B, Zambonato B, Scherer F, Merzoni J, Sekine L, Huls H, Cooper LJ, Paz A, Lee DA. Adoptive immunotherapy with double-bright (CD56bright /CD16bright ) expanded natural killer cells in patients with relapsed or refractory acute myeloid leukaemia: a proof-of-concept study. Br J Haematol. 2021;195(5):710-21. https://doi.org/10.1111/bjh.17751 DOI: https://doi.org/10.1111/bjh.17751
2. Meininger I, Carrasco A, Rao A, Soini T, Kokkinou E, Mjösberg J. Tissue-specific features of innate lymphoid cells. Trends Immunol. 2020;41(10):902-17. https://doi.org/10.1016/j.it.2020.08.009 DOI: https://doi.org/10.1016/j.it.2020.08.009
3. Srivastava RK, Sapra L, Bhardwaj A, Mishra PK, Verma B, Baig Z. Unravelling the immunobiology of innate lymphoid cells (ILCs): Implications in health and disease. Cytokine Growth Factor Rev. 2023;74:56-75. https://doi.org/10.1016/j.cytogfr.2023.09.002 DOI: https://doi.org/10.1016/j.cytogfr.2023.09.002
4. Eberl G, Colonna M, Di Santo JP, McKenzie AN. Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology. Science. 2015;348(6237):aaa6566. https://doi.org/10.1126/science.aaa6566 DOI: https://doi.org/10.1126/science.aaa6566
5. Coënon L, Villalba M. From CD16a biology to antibody-dependent cell-mediated cytotoxicity improvement. Front Immunol. 2022;13:913215. https://doi.org/10.3389/fimmu.2022.913215 DOI: https://doi.org/10.3389/fimmu.2022.913215
6. Wang W, Erbe AK, Hank JA, Morris ZS, Sondel PM. NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy. Front Immunol. 2015;6:368. https://doi.org/10.3389/fimmu.2015.00368 DOI: https://doi.org/10.3389/fimmu.2015.00368
7. Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S. Innate or adaptive immunity? The example of natural killer cells. Science. 2011;331(6013):44-9. https://doi.org/10.1126/science.1198687 DOI: https://doi.org/10.1126/science.1198687
8. Riggan L, Freud AG, O’Sullivan TE. True detective: unraveling group 1 innate lymphocyte heterogeneity. Trends Immunol. 2019;40(10):909-21. https://doi.org/10.1016/j.it.2019.08.005 DOI: https://doi.org/10.1016/j.it.2019.08.005
9. Adams NM, Diaz-Salazar C, Dang C, Lanier LL, Sun JC. Cutting edge: heterogeneity in cell age contributes to functional diversity of NK cells. J Immunol. 2021;206(3):465-70. https://doi.org/10.4049/jimmunol.2001163 DOI: https://doi.org/10.4049/jimmunol.2001163
10. A Adams NM, Grassmann S, Sun JC. Clonal expansion of innate and adaptive lymphocytes. Nat Rev Immunol. 2020;20(11):694-707. https://doi.org/10.1038/s41577-020-0307-4 DOI: https://doi.org/10.1038/s41577-020-0307-4
11. Wethington D, Ahmad S, Potempa M, Giuliani G, Aguilar OA, Poudel M, Grassmann S, Stewart W, Adams NM, Sun JC, Lanier LL, Das J. Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability. bioRxiv [Preprint]. 2025;2023.09.07.556760. https://doi.org/10.1101/2023.09.07.556760 DOI: https://doi.org/10.1101/2023.09.07.556760
12. Ljunggren HG, Kärre K. In search of the ‘missing self’: MHC molecules and NK cell recognition. Immunol Today. 1990;11(7):237-44. https://doi.org/10.1016/0167-5699(90)90097-s DOI: https://doi.org/10.1016/0167-5699(90)90097-S
13. Chen S, Zhu H, Jounaidi Y. Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization. Signal Transduct Target Ther. 2024;9(1):302. https://doi.org/10.1038/s41392-024-02005-w DOI: https://doi.org/10.1038/s41392-024-02005-w
14. Chretien AS, Devillier R, Granjeaud S, Cordier C, Demerle C, Salem N, Wlosik J, Orlanducci F, Gorvel L, Fattori S, Hospital MA, Pakradouni J, Gregori E, Paul M, Rochigneux P, Pagliardini T, Morey M, Fauriat C, Dulphy N, Toubert A, Luche H, Malissen M, Blaise D, Nunès JA, Vey N, Olive D. High-dimensional mass cytometry analysis of NK cell alterations in AML identifies a subgroup with adverse clinical outcome. Proc Natl Acad Sci U S A. 2021;118(22):e2020459118. https://doi.org/10.1073/pnas.2020459118 DOI: https://doi.org/10.1073/pnas.2020459118
15. Wang H, Tao Q, Wang Z, Zhang Q, Xiao H, Zhou M, Dong Y, Zhai Z. Circulating monocytic myeloid-derived suppressor cells are elevated and associated with poor prognosis in acute myeloid leukemia. J Immunol Res. 2020;2020:7363084. https://doi.org/10.1155/2020/7363084 DOI: https://doi.org/10.1155/2020/7363084
16. Denman CJ, Senyukov VV, Somanchi SS, Phatarpekar PV, Kopp LM, Johnson JL, Singh H, Hurton L, Maiti SN, Huls MH, Champlin RE, Cooper LJ, Lee DA. Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells. PLoS One. 2012;7(1):e30264. https://doi.org/10.1371/journal.pone.0030264 DOI: https://doi.org/10.1371/journal.pone.0030264
17. Silla L. Peripheral blood persistence and expansion of transferred non-genetically modified Natural Killer cells might not be necessary for clinical activity. Immunother Adv. 2023;3(1):ltac024. https://doi.org/10.1093/immadv/ltac024 DOI: https://doi.org/10.1093/immadv/ltac024
18. McCurdy SR, Radojcic V, Tsai HL, Vulic A, Thompson E, Ivcevic S, Kanakry CG, Powell JD, Lohman B, Adom D, Paczesny S, Cooke KR, Jones RJ, Varadhan R, Symons HJ, Luznik L. Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning. Blood. 2022;139(4):608-23. https://doi.org/10.1182/blood.2021013054 DOI: https://doi.org/10.1182/blood.2021013054
19. Silla LM, Chen J, Zhong RK, Whiteside TL, Ball ED. Potentiation of lysis of leukaemia cells by a bispecific antibody to CD33 and CD16 (Fc gamma RIII) expressed by human natural killer (NK) cells. Br J Haematol. 1995;89(4):712-8. https://doi.org/10.1111/j.1365-2141.1995.tb08406.x DOI: https://doi.org/10.1111/j.1365-2141.1995.tb08406.x
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Copyright (c) 2026 Annelise Pezzi, Vanessa Valim, Bruna Amorin, Bruna Zambonato, Aline Paz, Juliana Furlan, Marcelo Teixeira, Davi Martins, Michelle Flores Domingues , Raul Marques Rodrigues, Fabiane Spagnol, Juliana Nóbrega Trzesniak, Leo Sekine, Lucia Silla

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